Determination of valdecoxib and its metabolites in human urine by automated solid-phase extraction–liquid chromatography–tandem mass spectrometry

The induction and suppression of prostaglandin H2 synthase (cyclooxygenase) in human monocytes.

Jianmin Fu, Jaime L. Masferrer, Karen Seibert et al. · Journal of Biological Chemistry · 1990 · 943 citations · Full text

Life Sciences, Biochemistry, Pharmacology +13

4-[5-Methyl-3-phenylisoxazol-4-yl]- benzenesulfonamide, Valdecoxib:  A Potent and Selective Inhibitor of COX-2

John J. Talley, David Brown, Jeffery S. Carter et al. · Journal of Medicinal Chemistry · 2000 · 643 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +8

Preliminary study of the safety and efficacy of SC-58635, a novel cyclooxygenase 2 inhibitor: Efficacy and safety in two placebo-controlled trials in osteoarthritis and rheumatoid arthritis, and studies of gastrointestinal and platelet effects

Lee S. Simon, Frank L. Lanza, Peter E. Lipsky et al. · Arthritis & Rheumatism · 1998 · 477 citations · Full text

Medicine, Pharmacology, Pharmacotherapy +16

High-speed liquid chromatography/tandem mass spectrometry for the determination of drugs in biological samples

Thomas R. Covey, Edgar D. Lee, Jack D. Henion · Analytical Chemistry · 1986 · 250 citations

Pharmacy, Pharmaceutical Analysis, Pharmacology +16

Efficacy and safety of the COX-2 specific inhibitor valdecoxib in the management of osteoarthritis of the hip: a randomized, double-blind, placebo-controlled comparison with naproxen

William S. Makarowski, William W. Zhao, Terry Bevirt et al. · Osteoarthritis and Cartilage · 2002 · 108 citations · Full text

Medicine, Orthopaedic Surgery, Pharmacology +6