Piperidine mediated synthesis of <i>n</i>‐heterocyclic chalcones and their antibacterial activity

Abstract

Abstract magnified image The chalcones 1‐(2′‐hydroxy‐aryl)‐3‐(1‐indol‐3‐yl)‐prop‐2‐en‐1‐one (3) and 1‐(2′‐hydroxy‐aryl)‐3‐(2‐chloroquinolin‐3‐yl)‐prop‐2‐en‐1‐one (6) were synthesised by piperidine mediated condensation of an ethanolic solution of an o ‐hydroxyacetophenone (1) with corresponding heteroaryl‐3‐carboxaldehyde. The structures have been established on the basis of elemental (C, H, N) analysis, UV, IR, 1 H NMR spectral data. The compounds 3 and 6 were screened for antimicrobial activities against a variety of bacterial agents. J. Heterocyclic Chem., 2010.