μ-, δ-, κ- and ϵ-Opioid receptor modulation of the hypothalamic-pituitary-adrenocortical (HPA) axis: subchronic tolerance studies of endogenous opioid peptides

Dynorphin Is a Specific Endogenous Ligand of the κ Opioid Receptor

Charles Chavkin, Iain F. James, Avram Goldstein · Science · 1982 · 1.2K citations

Medicine, Medicinal Chemistry, Pharmacology +17

Stereospecific Binding of the Potent Narcotic Analgesic [ ³ H]Etorphine to Rat-Brain Homogenate

Eric J. Simon, Jacob M. Hiller, Irit Edelman · Proceedings of the National Academy of Sciences · 1973 · 1.1K citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17

Isolation of an endogenous compound from the brain with pharmacological properties similar to morphine

John Hughes · Brain Research · 1975 · 981 citations

Medicine, Neuroscience, Pharmacology +14

Differentiation of delta and mu opiate receptor localizations by light microscopic autoradiography.

Robert Goodman, Solomon H. Snyder, M. J. Kuhar et al. · Proceedings of the National Academy of Sciences · 1980 · 464 citations · Full text

Life Sciences, Neurobiology, Neuroscience +17

Properties of Opiate-Receptor Binding in Rat Brain

Candace B. Pert, Solomon H. Snyder · Proceedings of the National Academy of Sciences · 1973 · 439 citations · Full text

Medicine, Neurobiology, Pharmacology +17