Sensitive method for the quantification of urinary pyrimidine metabolites in healthy adults by gas chromatography–tandem mass spectrometry

Relationship between dihydropyrimidine dehydrogenase activity and plasma 5-fluorouracil levels with evidence for circadian variation of enzyme activity and plasma drug levels in cancer patients receiving 5-fluorouracil by protracted continuous infusion.

Barry Harris, Seng-Jaw Soong, Robert B. Diasio · PubMed · 1990 · 445 citations

Medicine, Pharmacokinetics, Pharmacology +17

Dihydropyrimidine dehydrogenase activity in human peripheral blood mononuclear cells and liver: population characteristics, newly identified deficient patients, and clinical implication in 5-fluorouracil chemotherapy.

Zhihong Lu, Ruiwen Zhang, Robert B. Diasio · PubMed · 1993 · 374 citations

Medicine, Oncology, Pharmacology +14

Molecular basis of the human dihydropyrimidine dehydrogenase deficiency and 5-fluorouracil toxicity.

Xiaoxiong Wei, Howard L. McLeod, J McMurrough et al. · Journal of Clinical Investigation · 1996 · 360 citations · Full text

Life Sciences, Genetics, Oncology +17

Dihydropyrimidine dehydrogenase deficiency and fluorouracil-related toxicity

G. Milano, M C Etienne, Muriel Barberi‐Heyob et al. · British Journal of Cancer · 1999 · 276 citations · Full text

Medicine, Oncology, Pharmacology +13

Rapid Screening of High-Risk Patients for Disorders of Purine and Pyrimidine Metabolism Using HPLC-Electrospray Tandem Mass Spectrometry of Liquid Urine or Urine-soaked Filter Paper Strips

Tetsuya Ito, André B. P. Kuilenburg, Albert H. Bootsma et al. · Clinical Chemistry · 2000 · 110 citations · Full text

Pharmacy, Pharmacology, Analytical Chemistry +16