Synthesis and biological evaluation of highly potent analogues of epothilones B and D

A Rapid Esterification by Means of Mixed Anhydride and Its Application to Large-ring Lactonization

Junji Inanaga, Kuniko Hirata, Hiroko SAEKI et al. · Bulletin of the Chemical Society of Japan · 1979 · 2.2K citations

Natural Sciences, Chemistry, Organic Chemistry +2

Taxol stabilizes microtubules in mouse fibroblast cells.

Peter B. Schiff, S. B. Horwitz · Proceedings of the National Academy of Sciences · 1980 · 2K citations · Full text

Life Sciences, Cell Biology, Pharmacology +17

Epothilons A and B: Antifungal and Cytotoxic Compounds from Sorangium cellulosum (Myxobacteria). Production, Physico-chemical and Biological Properties.

Klaus Gerth, Norbert Bedorf, Gerhard Höfle et al. · The Journal of Antibiotics · 1996 · 628 citations

Life Sciences, Biochemistry, Microbiology +13

Isolation and genetic characterization of human KB cell lines resistant to multiple drugs

Shin‐ichi Akiyama, Antonio Tito Fojo, John A. Hanover et al. · Somatic Cell and Molecular Genetics · 1985 · 553 citations

Medicine, Genetics, Oncology +12

Epothilone A and B—Novel 16‐Membered Macrolides with Cytotoxic Activity: Isolation, Crystal Structure, and Conformation in Solution

Gerhard Höfle, Norbert Bedorf, Heinrich Steinmetz et al. · Angewandte Chemie International Edition in English · 1996 · 514 citations

Pharmacy, Medicinal Chemistry, Pharmacology +15