Concepedia

Puerarin Induces Mitochondria-Dependent Apoptosis in Hypoxic Human Pulmonary Arterial Smooth Muscle Cells

Chan Chen, Chun Chen, Zhiyi Wang, Liangxing Wang, Lehe Yang, Ding Minjiao, Cheng Ding, Yu Sun, Quan Lin, Xiaoying Huang,

PLoS ONE · 2012 · 37 citations · 23 references

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Abstract

Puerarin promoted apoptosis in hypoxic HPASMCs by acting on the mitochondria-dependent pathway. These results suggest a new mechanism of puerarin relevant to the management of clinical hypoxic pulmonary hypertension.

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