Concepedia

Synthesis and pharmacological evaluation of new arylpiperazines. 3-{4-[4-(3-chlorophenyl)-1-piperazinyl]butyl}-quinazolidin-4-one — a dual serotonin 5-HT1A/5-HT2A receptor ligand with an anxiolytic-like activity

Andrzej J. Bojarski, Piotr A. Kowalski, Teresa Kowalska, Beata Duszyńska, Sijka Charakchieva‐Minol, E Tatarczyńska, Aleksandra Kłodzińska, E Chojnacka-Wójcik

Bioorganic & Medicinal Chemistry · 2002 · 31 citations · 37 references

DOI

Concepts

References

37

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

Yung-Chi Cheng, William H. Prusoff · Biochemical Pharmacology · 1973 · 12.9K citations

, , +14

Anxiolytic and anxiogenic drug effects on exploratory activity in an elevated plus-maze: A novel test of anxiety in the rat

Sharon Pellow, Sandra E. File · Pharmacology Biochemistry and Behavior · 1986 · 1.5K citations

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A simple and reliable conflict procedure for testing anti-anxiety agents

John R. Vogel, Bernard Beer, Donald E. Clody · Psychopharmacology · 1971 · 846 citations

, , +11

The involvement of subtypes of the 5-HT1 receptor and of catecholaminergic systems in the behavioural response to 8-hydroxy-2-(di-n-Propylamino) tetralin in the rat

Mark D. Tricklebank, Christian Forler, John R. Fozard · European Journal of Pharmacology · 1984 · 677 citations

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A pharmacological profile of the selective silent 5-HT1A receptor antagonist, WAY-100635

Elaine A. Forster, Ian A. Cliffe, David J. Bill et al. · European Journal of Pharmacology · 1995 · 611 citations

, , +8