IL-27, a novel anti-HIV cytokine, activates multiple interferon-inducible genes in macrophages

Abstract

IL-27 differentially regulates the gene expression between CD4 T cells and MDM. IL-27 significantly induces antiviral genes in MDM as does IFN-alpha, suggesting that IL-27 inhibits HIV replication in MDM via mechanism(s) similar to that of IFN-alpha.