Journal of Natural Products · 1991 · 50 citations · 0 references
PharmacyMedicinal ChemistryPharmacologyDrug DiscoveryMolecular VirologyStructure-activity RelationshipsAntiviral AgentsAntiviral PharmacologyMarine Bioactive CompoundsMarine Drug DiscoveryMarine Natural ProductsStructure-activity Relationship AnalysisAntimicrobial Marine CompoundsAntiviral Marine CompoundsBioactive Compounds From Marine SpongesMarine Sponge MetabolitesMarine-derived Antimicrobial CompoundsMarine-derived Antiviral CompoundsSponges As Drug SourcesSponges-derived Metabolites
A new sesquiterpene hydroquinone 1, which we call strongylin A, was isolated from the marine sponge Strongylophora hartmani. Its structure was determined through spectroscopic methods, including 2D-13C homonuclear correlation spectroscopy (INADEQUATE). Both 1 and its acetate derivative are active in in vitro assays against the P-388 tumor cell line and influenza strain PR-8.