Catalytic Oxidation of Imines Based on Methyltrioxorhenium/Urea Hydrogen Peroxide: A Mild and Easy Chemo- and Regioselective Entry to Nitrones

Abstract

[reaction: see text] The first successful catalytic oxidation procedure for the chemoselective conversion of imines to nitrones is reported. The reaction is general, high yielding, and user and environmentally friendly, and furnishes a solution to the yet unanswered issue of regioselective access to nitrones by oxidation of nitrogen derivatives.