Concepedia

Samarium Diiodide-Induced Reductive Cross-Coupling of Nitrones with Aldehydes and Ketones

Géraldine Masson, Sandrine Py, Yannick Vallée

Angewandte Chemie International Edition · 2002 · 136 citations · 33 references

DOI

Concepts

Abstract

Highly substituted amino alcohols or N-hydroxyamino alcohols can be prepared in good yield through a novel reductive cross-coupling of nitrones with aldehydes or ketones (see scheme). The reactions are fast and highly chemoselective, that is, no homocoupling or reduction products are formed.

References

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