Hepatic Accumulation and Intracellular Binding of Conjugated Bilirubin

Abstract

A B S T R A C T After the intravenous injection of un- conjugated [3H]bilirubin into normal Sprague-Dawley and Wistar R rats, radiolabeled bile pigments rapidly accumulated in the liver. By 1.5 min after injection, an average of 36% of the injected isotope was present in liver homogenates. Between 3 and 15 min, 37-64%