Formulation of Solid Dosage Forms to Overcome Gastric pH Interaction of the Factor Xa Inhibitor, BMS-561389

Comparison of Gastrointestinal pH in Dogs and Humans: Implications on the Use of the Beagle Dog as a Model for Oral Absorption in Humans

Chung Y. Lui, Gordon L. Amidon, Rosemary R. Berardi et al. · Journal of Pharmaceutical Sciences · 1986 · 199 citations

Pharmacy, Pharmacokinetics, Veterinary Physiology +16

Discovery of 1-(3‘-Aminobenzisoxazol-5‘-yl)-3-trifluoromethyl-<i>N</i>-[2-fluoro-4- [(2‘-dimethylaminomethyl)imidazol-1-yl]phenyl]-1<i>H</i>-pyrazole-5-carboxyamide Hydrochloride (Razaxaban), a Highly Potent, Selective, and Orally Bioavailable Factor Xa Inhibitor

Mimi L. Quan, Patrick Y. S. Lam, Qi Han et al. · Journal of Medicinal Chemistry · 2004 · 189 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +12

Gastric pH profiles of beagle dogs and their use as an alternative to human testing

Masayuki Akimoto · European Journal of Pharmaceutics and Biopharmaceutics · 2000 · 128 citations

Life Sciences, Animal Sciences, Veterinary Physiology +9

pH-Dependent Dissolution in Vitro and Absorption in Vivo of Weakly Basic Drugs: Development of a Canine Model

Rong Zhou, Paul Moench, Christopher L. Heran et al. · Pharmaceutical Research · 2005 · 119 citations

Pharmacy, Pharmaceutics, Pharmacology +16

pH-Related Changes in the Absorption of Dipyridamole in the Elderly

Tanya L. Russell, Rosemary R. Berardi, Jeffrey L. Barnett et al. · Pharmaceutical Research · 1994 · 114 citations · Full text

Pharmacy, Geriatric Medicine, Pharmacology +11