Effects of Dimethyl Sulfoxide, Pyrrolidine Dithiocarbamate, and Methylprednisolone on Nuclear Factor-κB and Heat Shock Protein 70 in a Rat Model of Hemorrhagic Shock

Abstract

Our results suggest that treatment with DMSO, PDTC, and MP can modulate the expression of NF-kappaB and HSP70 after HS in rats. This modulation may have potential effects in HS through inhibition of the NF-kappaB-dependent production of proinflammatory mediators.