Concepedia

Stem cell gene expression programs influence clinical outcome in human leukemia

Kolja Eppert, Katsuto Takenaka, Eric R. Lechman, Levi Waldron, Björn Nilsson, Peter van Galen, Klaus H. Metzeler, Armando G. Poeppl, Vicki Ling, Joseph Beyene,

Nature Medicine · 2011 · 1K citations · 57 references

Concepts

MedicineCancer BiologyOncologyGene ExpressionMolecular OncologyStem Cell BiologyCancer Stem Cell BiologyCancer Stem Cell MaintenanceCancer Stem CellsHematopoietic Stem Cell BiologyHematopoietic Stem CellsStem Cell DifferentiationCancer Stem Cell BiomarkersCancer Stem Cell EpigeneticsCancer Stem Cell TranscriptomicsHematopoietic Stem Cell Transcriptional RegulationStem Cell Gene RegulationStem Cell Marker ExpressionStemness Gene Signatures

References

57

Linear Models and Empirical Bayes Methods for Assessing Differential Expression in Microarray Experiments

Gordon K. Smyth · Statistical Applications in Genetics and Molecular Biology · 2004 · 12K citations

Life Sciences, Biostatistics, Bayesian Biostatistics +13

Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell

Dominique Bonnet, John E. Dick · Nature Medicine · 1997 · 6.9K citations

Medicine, Hematology, Oncology +14

Glioma stem cells promote radioresistance by preferential activation of the DNA damage response

Shideng Bao, Qiulian Wu, Roger E. McLendon et al. · Nature · 2006 · 6.4K citations

Medicine, Cancer Biology, Oncology +16

A cell initiating human acute myeloid leukaemia after transplantation into SCID mice

Tsvee Lapidot, Christian Sirard, Josef Vormoor et al. · Nature · 1994 · 4.7K citations

Medicine, Cell Biology, Hematology +14

An embryonic stem cell–like gene expression signature in poorly differentiated aggressive human tumors

Ittai Ben‐Porath, Matthew Thomson, Vincent J. Carey et al. · Nature Genetics · 2008 · 2.6K citations · Full text

Life Sciences, Cancer Biology, Oncology +16