Exendin-4, a glucagon-like peptide-1 receptor agonist, inhibits cell apoptosis induced by lipotoxicity in pancreatic β-cell line

Long-term exposure of rat pancreatic islets to fatty acids inhibits glucose-induced insulin secretion and biosynthesis through a glucose fatty acid cycle.

Yun Zhou, V. Grill · Journal of Clinical Investigation · 1994 · 687 citations · Full text

Life Sciences, Biochemistry, Endocrinology +17

Prolonged Exposure to Free Fatty Acids Has Cytostatic and Pro-Apoptotic Effects on Human Pancreatic Islets

R Lupi, Francesco Dotta, Lorella Marselli et al. · Diabetes · 2002 · 602 citations · Full text

Life Sciences, Cell Biology, Endocrinology +17

Glucagon-like Peptide-1 Receptor Signaling Modulates β Cell Apoptosis

Yazhou Li, Tanya Hansotia, Bernardo Yusta et al. · Journal of Biological Chemistry · 2002 · 590 citations · Full text

Life Sciences, Endocrinology, Pharmacology +17

Free Fatty Acids and Cytokines Induce Pancreatic β-Cell Apoptosis by Different Mechanisms: Role of Nuclear Factor-κB and Endoplasmic Reticulum Stress

Ilham Kharroubi, Laurence Ladrière, Alessandra K. Cardozo et al. · Endocrinology · 2004 · 578 citations

Life Sciences, Cell Biology, Endocrinology +17

Glucagon-like peptide-1 prevents beta cell glucolipotoxicity

Erik C. Joly, Marc Prentki, J. Buteau et al. · Diabetologia · 2004 · 332 citations · Full text

Life Sciences, Biochemistry, Endocrinology +5