Concepedia

Reversal of the enantioselectivity in aldol addition over immobilized di- and tripeptides: studies under continuous flow conditions

András A. Gurka, Imre Bucsi, Lenke Kovács, György Szőllősi, Mihály Bartók

RSC Advances · 2014 · 12 citations · 24 references

DOI

Concepts

Abstract

The reversal of the enantioselectivity in the heterogeneous asymmetric direct aldol reactions obtained over resin supported di- <italic>versus</italic> tripeptides was studied in a continuous-flow system.

References

24

Amino Acid Catalyzed Direct Asymmetric Aldol Reactions:  A Bioorganic Approach to Catalytic Asymmetric Carbon−Carbon Bond-Forming Reactions

Kandasamy Sakthivel, Wolfgang Notz, Tommy Bui et al. · Journal of the American Chemical Society · 2001 · 1.2K citations

, , +13

Thermodynamic control of asymmetric amplification in amino acid catalysis

Hiroshi Iwamura, Suju Mathew, David H. Wells et al. · Nature · 2006 · 396 citations

, , +16

New mechanistic studies on the proline-catalyzed aldol reaction

Benjamin List, Linh Hoang, Harry J. Martin · Proceedings of the National Academy of Sciences · 2004 · 333 citations · Full text

, , +11

Increased Structural Complexity Leads to Higher Activity:  Peptides as Efficient and Versatile Catalysts for Asymmetric Aldol Reactions

Philipp Krattiger, Roman Kovàsy, Jefferson D. Revell et al. · Organic Letters · 2005 · 269 citations

, , +17

Asymmetric Carbon–Carbon Bond Formation under Continuous‐Flow Conditions with Chiral Heterogeneous Catalysts

Tetsu Tsubogo, Takanori Ishiwata, Shū Kobayashi · Angewandte Chemie International Edition · 2013 · 224 citations

, , +17