Significance of angiotensin I-converting enzyme and angiotensin II type 1 receptor gene polymorphisms as risk factors for coronary heart disease

An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels.

Brigitte Rigat, C. Hübert, F Alhenc‐Gelas et al. · Journal of Clinical Investigation · 1990 · 3.8K citations · Full text

Life Sciences, Genetics, Molecular Genetics +13

A reporting system on patients evaluated for coronary artery disease. Report of the Ad Hoc Committee for Grading of Coronary Artery Disease, Council on Cardiovascular Surgery, American Heart Association

Austen Wg, Je. Edwards, RL Frye et al. · Circulation · 1975 · 3.3K citations · Full text

Medicine, Cardiology, Surgery +17

Deletion polymorphism in the gene for angiotensin-converting enzyme is a potent risk factor for myocardial infarction

François Cambien, Odette Poirier, Laure Lecerf et al. · Nature · 1992 · 1.9K citations

Medicine, Genetics, Molecular Genetics +14

PCR detection of the insertion/deletion polymorphism of the human angiotensin converting enzyme gene (DCP1) (dipeptidyl carboxypeptidase 1)

Brigitte Rigat, Christine Hübert, Pierre Corvol et al. · Nucleic Acids Research · 1992 · 1.3K citations · Full text

Life Sciences, Genetics, Molecular Genetics +11

Isolation of a cDNA encoding the vascular type-1 angiotensin II receptor

T J Murphy, R. Wayne Alexander, Kathy K. Griendling et al. · Nature · 1991 · 1.3K citations

Life Sciences, Molecular Biology, Physiology +8