Organic Letters · 2009 · 58 citations · 20 references
EngineeringStationary PhaseComplex MixturesMagnetic ResonanceOrganic ChemistryChemistrySeparation ScienceGas ChromatographyAnalytical ChemistryLiquid ChromatographyAdvanced SeparationLiquid StateBiophysicsPolymer ChemistryChromatographyChemical MeasurementDiffusion Coefficient DifferencesChromatographic AnalysisBiomolecular EngineeringMagnetic Resonance SpectroscopyPolymer ScienceMedicineSynthetic ChemistryNuclear Magnetic Resonance SpectroscopyDrug Analysis
A polymer assisted liquid state DOSY NMR technique, to extract the spectra of the individual components from mixtures in CDCl(3), is demonstrated. The enhancement of diffusion coefficient differences is achieved using a soluble polymer, polyvinylpyrrolidone, as the "stationary phase". The "separation" of analytes resembles normal-phase chromatography, for example, TLC. This method provides a fast, cheap, and simple technique to resolve the NMR spectra of complex mixtures.
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