The fixed structure of Licochalcone A by α, β-unsaturated ketone is necessary for anti-inflammatory activity through the inhibition of NF-κB activation

A cytokine-responsive IκB kinase that activates the transcription factor NF-κB

Joseph A. DiDonato, Makio Hayakawa, David M. Rothwarf et al. · Nature · 1997 · 2.1K citations · Full text

Inflammation, Cytokine, Transcriptional Regulation +11

The ubiquitinproteasome pathway is required for processing the NF-κB1 precursor protein and the activation of NF-κB

Vito J. Palombella, Oliver J. Rando, Alfred L. Goldberg et al. · Cell · 1994 · 2.1K citations

Transcriptional Regulation, Protein Function, Signal Transduction +14

IKK-1 and IKK-2: Cytokine-Activated IκB Kinases Essential for NF-κB Activation

Frank Mercurio, Hengyi Zhu, Brion W. Murray et al. · Science · 1997 · 2K citations

Immunology, Molecular Biology, Inflammation +20

Two new flavonoids and other constituents in licorice root. Their relative astringency and radical scavenging effects.

Tsutomu Hatano, Harumi Kagawa, Taeko Yasuhara et al. · Chemical and Pharmaceutical Bulletin · 1988 · 1.5K citations · Full text

Sinkiang Licorice, New Flavonoids, Biochemistry +9

IKK-γ is an essential regulatory subunit of the IκB kinase complex

David M. Rothwarf, Ebrahim Zandi, Gioacchino Natoli et al. · Nature · 1998 · 955 citations

Transcriptional Regulation, Signal Transduction, Signaling Pathway +14