Molecular analysis of T‐cell clonality with concomitant specific T‐cell proliferation <i>in vitro</i> in nickel‐allergic individuals

Abstract

In addition to proliferation assay, analysis of T-cell clonality may be a further means to characterize clinical hypersensitivity reactions on the basis of antigen-dependent oligoclonal T-cell expansion, as in the case of tissue-infiltrating lymphocytes.