Concepedia

Efficient Bayesian mixed-model analysis increases association power in large cohorts

Po‐Ru Loh, George Tucker, Brendan Bulik‐Sullivan, Bjarni J. Vilhjálmsson, Hilary K. Finucane, Rany M. Salem, Daniel I. Chasman, Paul M. Ridker, Benjamin M. Neale, Bonnie Berger,

Nature Genetics · 2015 · 1.8K citations · 42 references

Open access

Concepts

Life SciencesBiostatisticsGeneticsGenomicsQuantitative GeneticsStatistical GeneticsGenome-wide Association StudiesGenotype-phenotype Association AnalysisMixed Model AnalysisQuantitative Trait AnalysisRandom Effects ModelingBayesian Finite Mixture ModelsCohort Size EffectsGenome-wide Association Mixed ModelsGenome-wide Association Study DesignMixed Model Association TestingMixed-model Association AnalysisMolecular Genetic ArchitectureStatistical Power In Association Studies

References

42

Principal components analysis corrects for stratification in genome-wide association studies

Alkes L. Price, Nick J. Patterson, Robert M. Plenge et al. · Nature Genetics · 2006 · 10.7K citations

Public Health, Biostatistics, Genetics +12

Prediction of Total Genetic Value Using Genome-Wide Dense Marker Maps

T.H.E. Meuwissen, Ben J. Hayes, Michael E. Goddard · Genetics · 2001 · 8K citations · Full text

Life Sciences, Genetics, Molecular Genetics +17

Efficient Methods to Compute Genomic Predictions

P.M. VanRaden · Journal of Dairy Science · 2008 · 6.3K citations · Full text

Life Sciences, Bioinformatics, Genetics +12

LD Score regression distinguishes confounding from polygenicity in genome-wide association studies

Brendan Bulik‐Sullivan, Po‐Ru Loh, Hilary K. Finucane et al. · Nature Genetics · 2015 · 6.3K citations · Full text

Life Sciences, Biostatistics, Genetics +16

Common SNPs explain a large proportion of the heritability for human height

Jian Yang, Beben Benyamin, Brian P. McEvoy et al. · Nature Genetics · 2010 · 4.8K citations

Life Sciences, Genetics, Molecular Genetics +16