Concepedia

Oral <i>N</i>‐acetylcysteine attenuates pulmonary emphysema and alveolar septal cell apoptosis in smoking‐induced COPD in rats

Shan Cai, Ping Chen, Cheng Zhang, Jian‐Bo CHEN, Jie Wu

Respirology · 2009 · 59 citations · 20 references

DOI

Abstract

NAC attenuates lung damage, pulmonary emphysema and alveolar septal cell apoptosis by partly reversing the decrease in VEGF secretion and VEGFR2 protein expression in smoking-induced COPD in rats.

References

20

Vascular Endothelial Growth Factor Regulates Endothelial Cell Survival through the Phosphatidylinositol 3′-Kinase/Akt Signal Transduction Pathway

Hans-Peter Gerber, Amy E. McMurtrey, Joe Kowalski et al. · Journal of Biological Chemistry · 1998 · 2K citations · Full text

Vascular endothelial growth factor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of prematurity

Itzhak Hemo, Ahuva Itin, Jacob Pe’er et al. · Nature Medicine · 1995 · 1.6K citations

, , +8

Inhibition of VEGF receptors causes lung cell apoptosis and emphysema

Yasunori Kasahara, Rubin M. Tuder, Laimute Taraseviciene‐Stewart et al. · Journal of Clinical Investigation · 2000 · 1.1K citations · Full text

Endothelial Cell Death and Decreased Expression of Vascular Endothelial Growth Factor and Vascular Endothelial Growth Factor Receptor 2 in Emphysema

Yasunori Kasahara, Rubin M. Tuder, Carlyne D. Cool et al. · American Journal of Respiratory and Critical Care Medicine · 2001 · 687 citations

Increased gene expression for VEGF and the VEGF receptors KDR/Flk and Flt in lungs exposed to acute or to chronic hypoxia. Modulation of gene expression by nitric oxide.

Rubin M. Tuder, B E Flook, N. F. Voelkel · Journal of Clinical Investigation · 1995 · 595 citations · Full text

, , +21