Isolation and Structure of the Human Cancer Cell Growth Inhibitory Phakellostatin 4 from the Western Pacific Sponge Phakellia Costata

George R. Pettit, Jun-ping Xu, Zbigniew A. Cichacz, Jean M. Achmidt, Ann-Christine Dorsaz, Michael R. Boyd, Ronald L. Cerny

Heterocycles · 1995 · 28 citations · 0 references

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Abstract

Structural elucidation by high field 2D nsr and FAR-ms/ms techniques led to cyclo-(Pro-Thr-Pro-Phe-Ile-Phe-Ser) as the assignment for phakellistatin(4)a new cell growth inhibitory peptide from the Chuuk Archipelago marine sponge Phakellia costats ~vidence~-'~ is rapidly increasing that certain marine sponges in the class Demospongiae