Association of Lyn tyrosine kinase to the GM‐CSF and IL‐3 receptor common βc subunit and role of Src tyrosine kinases in DNA synthesis and anti‐apoptosis

Abstract

Lyn binds to betac derived peptides through multiple interactions, and may play an important role in betac phosphorylation. Src family kinases also play an essential role in GM-CSF mediated DNA synthesis, as well as an important role in anti-apoptosis in response to GM-CSF.