Concepedia

Hairy/enhancer-of-split related with YRPW motif protein 1 promotes osteosarcoma metastasis via matrix metallopeptidase 9 expression

Arisa Tsuru, Takao Setoguchi, Yukihiro Matsunoshita, Hiroko Nagao‐Kitamoto, Satoshi Nagano, M. Yokouchi, Shingo Maeda, Y Ishidou, Takuya Yamamoto, Setsuro Komiya

British Journal of Cancer · 2015 · 38 citations · 38 references

DOIFull text

Open access

Abstract

Our findings suggested that HEY1 augmented the metastasis of osteosarcoma via upregulation of MMP9 expression. Therefore, inhibition of HEY1 may be a novel therapeutic strategy for preventing osteosarcoma metastasis.

References

38

Notch Signaling Augments BMP9-Induced Bone Formation by Promoting the Osteogenesis-Angiogenesis Coupling Process in Mesenchymal Stem Cells (MSCs)

Junyi Liao, Qiang Wei, Yulong Zou et al. · Cellular Physiology and Biochemistry · 2017 · 2.8K citations · Full text

Notch/γ-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells

Johan H. van Es, Mariëlle van Gijn, Orbicia Riccio et al. · Nature · 2005 · 1.5K citations · Full text

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The Effect of Adjuvant Chemotherapy on Relapse-Free Survival in Patients with Osteosarcoma of the Extremity

Michael P. Link, Allen M. Goorin, Angela W. Miser et al. · New England Journal of Medicine · 1986 · 1.2K citations

Integration of TGF‐β/Smad and Jagged1/Notch signalling in epithelial‐to‐mesenchymal transition

Jiří Zavadil, Lukáš C̆ermák, Noemí Soto-Nieves et al. · The EMBO Journal · 2004 · 738 citations · Full text

Therapeutic antibody targeting of individual Notch receptors

Yan Wu, Carol Cain-Hom, Lisa Choy et al. · Nature · 2010 · 710 citations · Full text

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