Ligand-Selective Activation of μ-Opioid Receptor: Demonstrated with Deletion and Single Amino Acid Mutations of Third Intracellular Loop Domain

High-efficiency transformation of mammalian cells by plasmid DNA.

C Chen, Hiroto Okayama · Molecular and Cellular Biology · 1987 · 5.3K citations · Full text

Life Sciences, Biotechnology, Molecular Biology +13

Regulation of Gi and Go by mastoparan, related amphiphilic peptides, and hydrophobic amines. Mechanism and structural determinants of activity.

Tsutomu Higashijima, John P. Burnier, Elliott M. Ross · Journal of Biological Chemistry · 1990 · 602 citations · Full text

Life Sciences, Biochemistry, Pharmacology +16

Phosphorylation and Agonist‐Specific Intracellular Trafficking of an Epitope‐Tagged μ‐Opioid Receptor Expressed in HEK 293 Cells

James Arden, Veronica Segredo, Zaijie Wang et al. · Journal of Neurochemistry · 1995 · 299 citations

Life Sciences, Cell Biology, Pharmacology +17

-mu opiate receptor. Charged transmembrane domain amino acids are critical for agonist recognition and intrinsic activity.

Christopher K. Surratt, P. S. Johnson, Akiyoshi Moriwaki et al. · Journal of Biological Chemistry · 1994 · 241 citations · Full text

Medicine, Neuroscience, Pharmacology +17

Differential μ Opiate Receptor Phosphorylation and Desensitization Induced by Agonists and Phorbol Esters

Li Zhang, Yunkai Yu, Seamus Mackin et al. · Journal of Biological Chemistry · 1996 · 162 citations · Full text

Medicine, Pharmacology, Cell Signaling +16