Helvetica Chimica Acta · 1961 · 27 citations · 4 references
Natural SciencesChemistryMedicinal ChemistryOrganic ChemistryStructure-activity RelationshipsSynthetic Medicinal ChemistryHeterocycle SynthesisHeterocyclic ChemistryOrganic SynthesisRetrosynthetic AnalysisBioactive HeterocyclesHeterocycle FunctionalizationIsoquinoline AlkaloidsIsoquinoline ChemistryIsoquinoline SynthesisMedicinal Chemistry ApplicationsMedicinal Heterocycles
The synthesis of substituted l‐phenylalkyl‐2‐alkyl‐l.2,3,4,5,6,7,8‐octahydroisoquinolines and their resolution into optical antipodes are described. 1‐(Nitrophenylalkyl)‐2‐methylderivatives are potent analgesics.
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John T. Plati, William H. Strain, Stafford L. Warren · Journal of the American Chemical Society · 1943 · 32 citations