JTP‐426467 acts as a selective antagonist for peroxisome proliferator‐activated receptor γ <i>in vitro</i> and <i>in vivo</i>

Abstract

JTP-426467 acted as a pure and potent PPARgamma antagonist in vitro. Interestingly, JTP-426467 completely antagonized the effects of PPARgamma agonist BRL49653 in an obese diabetic model. JTP-426467 may be a useful tool for the study of PPARgamma in biological and physiological function.