FEBS Letters · 1998 · 291 citations · 24 references
Life SciencesCell BiologyImmunologyApoptosisInflammationSignal TransductionApoptosis RegulationApoptotic SignalingCell DeathDeath ReceptorsInflammatory SignalingProgrammed Cell DeathApoptosis Signaling In CancerCell Death Signaling PathwaysDeath DomainsReceptorsTnfr1 SignalingTumor Necrosis Factor Receptor SignalingTumor Necrosis Factor SuperfamilyTumor Necrosis Factor-mediated Apoptosis
Tumor nectosis factor (TNF) receptors are key players in inflammation and immune regulation. A new member of this family, termed death receptor-6 (DR6), has been identified. Like other death receptors, DR6 is a type I transmembrane receptor, possesses four extracellular cysteine-rich motifs and a cytoplasmic death domain. DR6 is expressed in most human tissues and abundant transcript was detected in heart, brain, placenta, pancreas, thymus, lymph node and several non-lymphoid cancer cell lines. DR6 interacts with TRADD, which has previously been shown to associate with TNFR1. Furthermore, ectopic expression of DR6 in mammalian cells induces apoptosis and activation of both NF-kappaB and JNK.
24