Induction of Interferon in Hereditarily Asplenic Mice With and Without a Neonatal Spleen Cell Transplant

Abstract

Interferon production in hereditarily asplenic and normal mice following intravenous injection of Newcastle disease virus was compared. Serum from asplenic mice showed a significantly lower interferon level than normal littermates. A neonatal spleen cell transplant markedly enhanced interferon production in asplenic mice to the extent that they were able to produce amounts of interferon approximately the same as normal littermates with spleen.