«Alkaloide» in tierischem und menschlichem Gewebe. 6. Mitteilung [1] [2]. Synthese und absolute Konfiguration chiraler 2, 3, 10, 11 ‐ Tetrahydroxy‐8‐methyl‐berbine [3]

Abstract

Synthesis and absolute configuration of chiral 2, 3, 10, 11‐tetrahydroxy‐8‐methylberbines [3] . The synthesis and absolute configuration of the four optically active berbines Xa, b and XIa, b are described. These compounds consitute potential ‘alkaloids’ obtained by condensation of either R ‐(+) or S ‐(−)‐norlaudanosoline (THP, III) with acetaldehyde, a major metabolite of ethanol.