Concepedia

The adapter proteins of TLRs, TRIF and MYD88, are upregulated in depressed individuals

Batool Hajebrahimi, Masoud Bagheri, Gholamhossein Hassanshahi, Mahmood Nazari, Reza Bidaki, Hassan Khodadadi, Mohammad Kazemi Arababadi, Derek Kennedy

International Journal of Psychiatry in Clinical Practice · 2013 · 31 citations · 13 references

DOI

Abstract

Based on the current results, it seems that chronic inflammation in depressed patients correlates to the over expression of TRIF and MYD88 genes. Our results show a possible link between the reported increases of chronic inflammation in depressed individuals with unbalanced expression of genes that regulate immunity.

References

13

Screening Depressed Patients in Family Practice

Aaron T. Beck, Roy W. Beck · Postgraduate Medicine · 1972 · 1.8K citations

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Macrophages Generate Reactive Oxygen Species in Response to Minimally Oxidized Low-Density Lipoprotein

Yun Soo Bae, Jee Hyun Lee, Soo Ho Choi et al. · Circulation Research · 2008 · 418 citations · Full text

Sustained Low-Grade Pro-inflammatory State in Unmedicated, Remitted Women with Major Depressive Disorder as Evidenced by Elevated Serum Levels of the Acute Phase Proteins C-reactive Protein and Serum Amyloid A

Mitchel A. Kling, Salvatore Alesci, György Csákó et al. · Biological Psychiatry · 2006 · 108 citations · Full text

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Association Between Type D Personality, Depression, and Oxidative Stress in Patients With Chronic Heart Failure

Nina Kupper, Yori Gidron, Jobst B. Winter et al. · Psychosomatic Medicine · 2009 · 85 citations

TLR3 signaling in a hepatoma cell line is skewed towards apoptosis

Elina Zorde Khvalevsky, Ludmila Rivkin, Jacob Rachmilewitz et al. · Journal of Cellular Biochemistry · 2007 · 84 citations