Effect of Anti Light‐Chain Antibodies on Rat Leukocytes in Vitro

Abstract

The effect of the IgG fraction of rabbit anti rat L‐chain antibodies (aL) and their Fab fragments (Fab aL) on rat blood leukocytes cultured in vitro has been examined. Undigested aL increased the thymidine uptake in both mixed and unmixed leukocyte cultures over a very wide dose range. Fab aL had no effect on either mixed or unmixed leukocyte cultures. The nature of T lymphocyte receptors is briefly discussed.