Nucleosides and Nucleotides · 1999 · 24 citations · 3 references
MedicineMolecular BiologyOncologyMolecular ImagingMolecular OncologyRadionuclide TherapyOncologic Nuclear ImagingRadiobiological ConsiderationsRadiopharmaceutical TherapyRadiopharmaceuticalsTargeted Radionuclide TherapyTumor ImagingPyrimidine ChemistryRadioiodine ImagingRadioligand Therapy ImagingTargeted Molecular Imaging AgentsTargeted Radionuclide ImagingTumor RadiosensitivityTumor Radiotracer ImagingTumor Uptake Mechanisms
Selective radiolabelling and imaging of transduced HSV tk expressing cells was studied using [123I]IVFRU, [125I]FIRU and [125I]FIAU. Although all three radionucleosides accumulated in the KBALB-STK transduced murine tumour line in vitro and in vivo, [125I]FIRU provided optimal performance in terms of selectivity for HSV tk expressing cells and % of injected dose accumulating in the tumor.
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Imaging the expression of transfected genes in vivo.
Günther Stockhammer, Revathi Desai, Hisao Uehara et al. · PubMed · 1995 · 386 citations