THE CONTROL OF LEUKOCYTE GLYCOLYSIS

Abstract

lsolated human blood leukocytes have a predominantly aerobic glycolytic metabolism, but the rates of lactic acid production per cell are significantly lower in chronic myelocytic leukemia and chronic lymphocytic leukemia leukocytes than in normal ones. An attempt was made to explain these differences by identifying the rate-limiting or master reaction in the three tissues. (C.H.)