NMR evidence for planar chirality in natural porphyrins

Abstract

Abstract The 1 H NMR spectra of several six‐coordinate cobalt(III) porphyrins of general formula L 2 Co(DPDME)CI, where DPDME=deuteroporphyrin dimethyl ester and L is an optically active ligand, have been measured at 250 or 400 MHz. In a few cases, two signals of equal intensity are observed for the L ligand protons. This magnetic non‐equivalence, which never exceeds 0.04 ppm, is thought to arise from the planar chirality of the porphyrin ring, which makes a proton in the ligand L above the porphyrin ring and the corresponding proton below this ring diastereotopic.