Lissoclimides, Cytotoxic Diterpenes from<b>Lissoclinum voeltzkowi</b>Michaelsen

Abstract

Abstract Chlorolissoclimide, a monochloro diterpene, was identified in Lissoclinum voeltzkowi Michaelsen, a New-Caledonian tunicate. Its structure was determined in relation to that of the previously described dichlorolissoclimide. In vitro cytotoxicity, structure-activity relationships, biosynthetic origin and involvement in human food poisoning are discussed.