A route, via tetraquinane, to the 5-8-5 carbocyclic nucleus of fusicoccins and ophiobolins

Abstract

Short, stereoselective syntheses of dicyclopenta[a,d]cyclo-octane-based diones (14) and (+)-(22)via a 5-5-5-5→5-8-5 strategy are reported; our approach constitutes an effective methodology for constructing fusicoccane and ophiobolane-type natural products.