Awakening properties of newly discovered highly selective H3 receptor antagonists in rats

GSK189254, a Novel H3 Receptor Antagonist That Binds to Histamine H3 Receptors in Alzheimer’s Disease Brain and Improves Cognitive Performance in Preclinical Models

Andrew D. Medhurst, A.R. Atkins, I.J.M. Beresford et al. · Journal of Pharmacology and Experimental Therapeutics · 2007 · 301 citations

Medicine, Medicinal Chemistry, Pharmacology +13

An inverse agonist of the histamine H3 receptor improves wakefulness in narcolepsy: Studies in orexin−/− mice and patients

Jian‐Sheng Lin, Yves Dauvilliers, Isabelle Arnulf et al. · Neurobiology of Disease · 2007 · 264 citations · Full text

Medicine, Neuroscience, Pharmacology +16

BF2.649 [1-{3-[3-(4-Chlorophenyl)propoxy]propyl}piperidine, Hydrochloride], a Nonimidazole Inverse Agonist/Antagonist at the Human Histamine H3 Receptor: Preclinical Pharmacology

Xavier Ligneau, David Perrin, Laurent Landais et al. · Journal of Pharmacology and Experimental Therapeutics · 2006 · 234 citations

Medicine, Neuroscience, Pharmacology +10

Involvement of histaminergic neurons in arousal mechanisms demonstrated with H3-receptor ligands in the cat

Jian‐Sheng Lin, Kazuya Sakai, Giovanna Vanni-Mercier et al. · Brain Research · 1990 · 220 citations

Life Sciences, Neurobiology, Neuroscience +13

The brain H3-receptor as a novel therapeutic target for vigilance and sleep–wake disorders

Régis Parmentier, Christelle Anaclet, C. Guhennec et al. · Biochemical Pharmacology · 2007 · 168 citations

Medicine, Neuroscience, Pharmacology +16