Concepedia

N-Aryl-N′-(chroman-4-yl)ureas and thioureas display in vitro anticancer activity and selectivity on apoptosis-resistant glioblastoma cells: Screening, synthesis of simplified derivatives, and structure–activity relationship analysis

Eric Goffin, Delphine Lamoral‐Theys, Nicolas Tajeddine, Pascal De Tullio, Ludivine Mondin, Florence Lefranc, Philippe Gailly, Bernard Rogister, Róbert Kiss, Bernard Pirotte

European Journal of Medicinal Chemistry · 2012 · 31 citations · 27 references

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27

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

Christopher A. Lipinski, Franco Lombardo, Beryl W. Dominy et al. · Advanced Drug Delivery Reviews · 1997 · 11.2K citations

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Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial

Roger Stupp, Monika E. Hegi, Warren Mason et al. · The Lancet Oncology · 2009 · 7.8K citations

, , +17

Virtual Computational Chemistry Laboratory – Design and Description

Igor V. Tetko, Johann Gasteiger, Roberto Todeschini et al. · Journal of Computer-Aided Molecular Design · 2005 · 1.5K citations

, , +9

Role of autophagy in temozolomide-induced cytotoxicity for malignant glioma cells

Takao Kanzawa, Isabelle M. Germano, Tadashi Komata et al. · Cell Death and Differentiation · 2004 · 984 citations

, , +11

Passive Permeability and P-Glycoprotein-Mediated Efflux Differentiate Central Nervous System (CNS) and Non-CNS Marketed Drugs

Kelly M. Mahar Doan, Joan E. Humphreys, Lindsey O. Webster et al. · Journal of Pharmacology and Experimental Therapeutics · 2002 · 626 citations

, , +17