ChemBioChem · 2007 · 16 citations · 2 references
Life SciencesBiochemistryChemistryCell SignalingSensory PhysiologySignal TransductionSensory Receptor PhysiologyCovalent Protein AdductionCovalent Protein BindingIon Channel Receptor SignalingLock-and-key MechanismLock-and-key ModelReactivity
Taste the seasoning. Sensing of the pungent principles of mustard and horseradish is caused by a covalent protein modification that activates the ion-channel receptor involved rather than a direct lock-and-key mechanism.
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Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines
Lindsey J. Macpherson, Adrienne E. Dubin, Michael J. Evans et al. · Nature · 2007 · 1.1K citations · Full text