Concepedia

Lock-and-key Model

The "Lock-And-Key Model" is a theoretical framework in enzymology that explains enzyme specificity by proposing a rigid, complementary fit between the active site of an enzyme and its substrate, analogous to a key fitting precisely into a lock.

100

Publications

5.7K

Citations

363

Authors

161

Institutions

Publications per year

2017–2026

23

Variants

Lock-and-key Mechanism

Parents

Publications

100

The Key–Lock Theory and the Induced Fit Theory

Daniel E. Koshland · Angewandte Chemie International Edition in English · 1995 · 738 citations

, , +15

The Lock-and-Key Hypothesis: Evolutionary and Biosystematic Interpretation of Insect Genitalia

Arthur M. Shapiro, Adam Porter · Annual Review of Entomology · 1989 · 292 citations

, , +16

Rusting of the Lock and Key Model for Protein-Ligand Binding

William L. Jorgensen · Science · 1991 · 228 citations

, , +14

Selective Isomerization of Hydrocarbon Chains on External Surfaces of Zeolite Crystals

Johan A. Martens, Wim Souverijns, Wim H. Verrelst et al. · Angewandte Chemie International Edition in English · 1995 · 208 citations

, , +17

170 Years of “Lock-and-Key”: Genital Morphology and Reproductive Isolation

John P. Masly · International Journal of Evolutionary Biology · 2011 · 192 citations · Full text

, , +17

1–5 of 100

Authors

363

  1. YX
    Yunjie Xu

    University of Alberta, Canada

    4 publications · 131 citations

    4

    h-index

  2. NB
    Nicole Borho

    University of Göttingen, Germany

    3 publications · 110 citations

    3

    h-index

  3. AM
    Arthur M. Shapiro

    University of California, Davis, United States

    3 publications · 340 citations

    3

    h-index

  4. GN
    Gábor Náray‐Szabó

    Eötvös Loránd University, Hungary

    3 publications · 50 citations

    3

    h-index

  5. AK
    A. Keith Dunker

    Indiana University – Purdue University Indianapolis, United States

    2 publications · 113 citations

    2

    h-index

1–5 of 363

Institutions

161

  1. Centre National de la Recherche Scientifique

    Paris, France

    7 h-index

    7 publications

    363 citations

  2. University of Alberta

    Edmonton, Canada

    5 h-index

    5 publications

    212 citations

  3. The University of Tokyo

    Tokyo, Japan

    4 h-index

    4 publications

    239 citations

  4. Kyoto University

    Kyoto, Japan

    4 h-index

    4 publications

    135 citations

  5. Brookhaven National Laboratory

    Upton, United States

    3 h-index

    3 publications

    111 citations

  6. Universidad de Costa Rica

    San José, Costa Rica

    3 h-index

    3 publications

    115 citations

  7. Tokyo Institute of Technology

    Tokyo, Japan

    3 h-index

    3 publications

    48 citations

  8. University of South Florida

    Tampa, United States

    2 h-index

    2 publications

    113 citations

1–8 of 161

Venues

  1. 5

    h-index

  2. Evolution

    4 publications · 383 citations

    4

    h-index

  3. Angewandte Chemie International Edition

    4 publications · 143 citations

    4

    h-index

  4. Bioinformatics

    3 publications · 146 citations

    3

    h-index

  5. Journal of the American Chemical Society

    JACS · 3 publications · 129 citations

    3

    h-index

1–5