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Design of small molecule inhibitors of acetyl-CoA carboxylase 1 and 2 showing reduction of hepatic malonyl-CoA levels in vivo in obese Zucker rats

Small Molecule InhibitorsMetabolic SyndromeBiochemistryMedicineLiver PhysiologyPhysiologyHepatic Malonyl-coa LevelsMetabolic RegulationHepatotoxicityObese Zucker RatsFatty Liver DiseaseMetabolismPharmacologyDrug DiscoveryHealth Sciences