Synthesis and Application of a Fluorous Lawesson's Reagent:  Convenient Chromatography-Free Product Purification

Abstract

[reaction: see text] A fluorous analogue of Lawesson's reagent for thionation of carbonyl compounds has been developed and its use demonstrated on a series of amides, esters, and ketones. The separation of the Lawesson's reagent-derived byproducts can be achieved by a simple fluorous solid-phase extraction.