Journal of Natural Products · 2000 · 38 citations · 10 references
PharmacyBiochemistryMedicinal ChemistryDrug DiscoverySteroid BiochemistryStructure-activity RelationshipsMarine Bioactive CompoundsMarine Drug DiscoveryMarine Natural ProductsSteroid BiosynthesisSteroid StructureTerpenoid BiosynthesisAntiproliferative AgentsAntiproliferative Drug ActionBioactive Compounds From Marine SpongesBioactive Marine MetabolitesMarine Sponge MetabolitesMarine TerpenoidsSponges As Drug SourcesSponges-derived Metabolites
Three new scalarane sesterterpenoids-hyrtiolide (1), 16-hydroxyscalarolide (2), and 12-deacetyl-Delta(17)-hyrtial (3), were isolated from Okinawan sponge Hyrtios erectus, along with scalarolide (4) and 12-deacetylhyrtial (5). The structures of new compounds 1-3 were determined by spectroscopic analysis and chemical conversions. Compounds 3 and 5 showed antiproliferative activity toward KB cells.
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Scalarin, a new pentacyclic C-25 terpenoid from the sponge Cacospongia scalaris
Ernesto Fattorusso, Silvana Magno, C. Santacroce et al. · Tetrahedron · 1972 · 100 citations