Adenovirus-mediated gene transfer of soluble vascular cell adhesion molecule to porcine interposition vein grafts.

Abstract

We conclude that ex vivo gene transfer before vein grafting is feasible using a replication-deficient recombinant adenovirus and results in a high level of gene expression in vivo. The potential for this approach to prevent early vein graft thrombosis or accelerated vein graft atherosclerosis requires further evaluation.