The metabolism of lindane and its metabolites gamma‐2, 3, 4, 5, 6‐pentachlorocyclohexene, pentachlorobenzene, and pentachlorophenol in rats and the pathways of lindane metabolism

Abstract

Abstract The metabolism of lindane and its metabolites, gamma‐PCCH, PCB, and PCP, has been studied in rats. Urine, faeces, blood and important organs were analyzed for free metabolites and those bound as beta‐glucuronides. TeCCOL was identified as a main metabolite by GC/MS and gamma‐PCCH has been evaluated toxicologically. A degradation scheme, based on experimental results and comprising only one hypothetical metabolite is proposed and discussed.