DNA-Induced Transformation in <i>Drosophila:</i> Genetic Analysis of Transformed Stocks

Abstract

The exosome model of transformation in Drosophila melanogaster proposes that DNA fragments enter the cells of treated individuals and become firmly associated with their homologous chromosome segments, but are never integrated into the linear structure of the chromosome. This paper reports results that validate two central predictions of the model: (a) the introduced genetic information usually maps precisely at the site of the target locus, and (b) the original chromosomal information is still present at that site.