Accelerating Reactions with Microreactors at Elevated Temperatures and Pressures: Profiling Aminocarbonylation Reactions

Abstract

Squeeze play: Pressurized microreactor systems greatly expand the range of reaction conditions and accelerate gas–liquid mass transfer. Heck aminocarbonylation reactions (see scheme) exemplify the potential for the quick and safe scanning of reagents and reaction conditions. The yield of amide increases with an increase in temperature and the selectivity for α-ketoamide production (n=2) increases at lower temperature and higher pressure. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2007/z604175_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.